Evaluation of Xpert MTB/RIF assay performance in diagnosing extrapulmonary tuberculosis among adults in a tertiary care centre in India.
نویسندگان
چکیده
According to the World Health Organization Global Tuberculosis Report from 2013, there were 8.6 million incident tuberculosis (TB) cases globally and India alone contributed 26% to this global scenario [1]. Of the five countries with the largest number of TB incident cases in 2012, India tops the list [1]. Epidemiological data suggest that extrapulmonary TB (EPTB) constitutes about 15–20% of all TB cases, but among HIV-TB co-infection it accounts for 50% of the cases [2]. Out of 1 183 373 new TB cases notified globally, 234 029 (20%) were reported to be cases of EPTB [1].
منابع مشابه
Rapid and effective diagnosis of tuberculosis and rifampicin resistance with Xpert MTB/RIF assay: a meta-analysis.
OBJECTIVES Xpert MTB/RIF (Cepheid) assay has been introduced for the diagnosis of tuberculosis (TB) and RIF-resistance. The meta-analysis was used to establish the overall accuracy of Xpert MTB/RIF assay for diagnosing TB and RIF-resistance. METHODS Based on comprehensive searches of the Pubmed and Embase, we identified outcome data from all articles estimating diagnostic accuracy with Xpert ...
متن کاملEvaluation of Xpert MTB/RIF in detection of pulmonary and extrapulmonary tuberculosis cases in China
Background: To evaluate the performance of Xpert MTB/RIF assay for direct detection of Mycobacterium tuberculosis (Mtb) and rifampin resistance in pulmonary and extrapulmonary tuberculosis (TB) patients in China. Material/Methods: We prospectively enrolled 506 TB patients to evaluate sensitivity and specificity of Xpert MTB/ RIF by comparing with Mtb culture, fluorescent staining smear microsco...
متن کاملRapid and Accurate Detection of Mycobacterium tuberculosis in Sputum Samples by Cepheid Xpert MTB/RIF Assay—A Clinical Validation Study
BACKGROUND A crucial impediment to global tuberculosis control is the lack of an accurate, rapid diagnostic test for detection of patients with active TB. A new, rapid diagnostic method, (Cepheid) Xpert MTB/RIF Assay, is an automated sample preparation and real-time PCR instrument, which was shown to have good potential as an alternative to current reference standard sputum microscopy and cultu...
متن کاملRapid diagnosis of tuberculosis using Xpert MTB/RIF assay - Report from a developing country
OBJECTIVE To evaluate the diagnostic accuracy of the Xpert MTB/RIF assay for the detection of M. tuberculosis in pulmonary and extrapulmonary specimens and to compare it with conventional techniques. METHODS During a period of 10 months from December 2012 through September 2013, two hundred and forty five clinically TB suspects were enrolled for Xpert MTB\RIF assay. The cohort comprised of 20...
متن کاملRapid Diagnosis of Pulmonary and Extrapulmonary Tuberculosis in HIV-Infected Patients. Comparison of LED Fluorescent Microscopy and the GeneXpert MTB/RIF Assay in a District Hospital in India
HIV-related tuberculosis is difficult to diagnose and is associated with high morbidity and mortality. Recently, the World Health Organization has endorsed the GeneXpert MTB/RIF (Xpert) assay for the diagnosis of pulmonary tuberculosis in HIV-infected patients from developing countries, but information about the use of Xpert for the diagnosis of extrapulmonary tuberculosis is scarce. In this st...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- The European respiratory journal
دوره 44 4 شماره
صفحات -
تاریخ انتشار 2014